胡显镜 副研究员
胡显镜，医学博士，副研究员，博士后合作导师、硕士生导师，东莞市特色人才，广东医科大学高层次人才。国家中药现代化工程技术研究中心东莞分中心副主任、东莞市中医药防治消化道疑难病证重点实验室（常务副主任）、东莞市毒性中药临床应用与基础研究重点实验室（常务副主任）、东莞市慢性炎症防治重点实验室副主任。博士毕业于暨南大学，香港浸会大学博士后。主持国家级、省市级项目10项。在Cancer Letter; Cell Death Dis; Int J Biol Macromol; J Ethnopharmacol等期刊发表SCI论文34篇；授权8项专利。《Chinese Medicine》、《Chinese Herbal Medicines》等期刊青年编委，广东省中西医结合学会自然疗法专业委员会常务委员，广东省药理学学会抗炎免疫药理专业委员会委员。
研究方向：消化道肿瘤形成机制与中医药防治作用研究。
主持的科研项目：
[1]国家外国专家个人类项目(Y类，国家人力资源部)，基于“钩钓策略”的掌叶酒瓶树抗肝癌药效物质基础及靶标发现研究，Y20240168。
[2]广东省自然科学基金面上项目，2023A1515011116，基于与肠道菌群双向调控机制探讨中药活性分子Ardisiacrispin B治疗溃疡性结肠炎及其调控机体Th17/Treg免疫平衡作用。
[3]广东省中医药局项目面上项目，20241159，冬虫夏草基于调控肠-肺交互机制改善小鼠肺纤维化作用研究。
[4]东莞市社会发展科技项目重点项目，20231800939832；基于改善肝肠循环研究中医经方黄连平胃散治疗溃疡性结肠炎合并肝损伤作用及其分子机制。
[5]湛江市科技发展专项基金竞争分配性项目，2022A01003，基于调控“肝-肠循环”研究琴叶榕防治原发性肝癌作用及其制剂开发。
[6]国家自然科学基金青年基金，81503303，海洋中药毛蚶新多肽H3在乏氧微环境
下抗肝癌作用及其机制研究。
[7]广东省自然科学基金，博士启动基金，2015A030310226，海洋中药毛蚶新多肽
H3抗肝癌及靶向PI3K/AKT/mTOR作用机制研究。
[8]广东省自然科学基金，自由探索项目，2016A030313825，基于乏氧微环境下研究
毛蚶新多肽H3抗肝癌及其作用机理。
近五年部分代表作：
[1]Xianjing Hu#, Sarwat Fatima#, Minting Chen,Tao Huang, Yuen Wa Chen, Ruihong Gong, Hoi Leong Xavier Wong, Rongmin Yu, Liyan Song, Hiu Yee Kwan*, Zhaoxiang Bian*. Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level. Cell Death Dis, 2021, 12: 1053.
[2]Xianjing Hu#, Sarwat Fatima#, Minting Chen#, Keyang Xu, Chunhua Huang, Rui-Hong Gong, Tao Su, Hoi Leong Xavier Wong, Zhaoxiang Bian* and Hiu Yee Kwan*. Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism. Cell Death Dis, 2021, 12(8): 791.
[3]Weibo Dai#, Xiaoyan Pang#, Weiwen Peng#, Xinyi Zhan, Chang Chen, Wenchang Zhao, Congyan Zeng, Quanxi Mei, Qilei Chen, Weihong Kuang*, Zhanping Gou and Xianjing Hu*. Liver protection of a low-polarity fraction from Ficus pandurata Hance, prepared by supercritical CO2 fluid extraction, on CCl4-induced acute liver injury of mice via inhibiting apoptosis and ferroptosis mediated by strengthening anti-oxidation. Molecules, 2023, 28, 2078.
[4]Xiaokang Wang#, Xianjing Hu#, Chunxiao Ye, Jingqian Zhao, Shing Cheng Tan, Liangbin Zhou, Chenyu Zhao, Kit Hang Wu, Xixiao Yang, Jinbin Wei*, Maoxun Yang*. Astragalus polysaccharide enhances voriconazole metabolism under inflammatory conditions through the gut microbiota. J Clin Transl Hepatol. 2024,12(5): 481-495.
[5]Xinyi Zhan#, Weijie Peng#, Zhuqiang Wang#, Xin Liu, Weibo Dai*, Quanxi Mei*, Xianjing Hu*. Polysaccharides from garlic protect against liver injury in DSS-induced inflammatory bowel disease of mice via suppressing pyroptosis and oxidative damage. Oxid Med Cell Longev, 2022, 2022: 2042163.
[6]Weibo Dai#, Chang Chen#, Gengting Dong#, Guangru Li, Weiwen Peng, Xin Liu, Jing Yang, Leyu Li*, Ruiyan Xu, Xianjing Hu*. Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation. J Ethnopharmacol, 2022, 294: 115338.
[7]Weibo Dai#, Chang Chen#, Huiting Feng#, Guangru Li, Weiwen Peng*, Xin Liu, Jing Yang, Xianjing Hu*. Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis. J Ethnopharmacol, 2021, 275: 114140.
[8]Weibo Dai#, Jing Yang#, Haili Cao#, Zhuqiang Wang, Guangru Li, Xiwen Zhong,Weiwen Peng, Chang Chen, Xin Liu, Congyan Zeng* and Xianjing Hu*. Clinical evidence-guided anti-rheumatoid arthritis study of Shuji tablet in adjuvant-induced arthritis rats and mechanism exploration via network pharmacological approach. Front Pharmacol, 2021, 12: 694507.
[9]Xianjing Hu#, Weiming Zheng#, Yuanyuan Luo#, Xiaozheng Ou, Liyan Song*, Sirui Zhang, Tingsha He, Zhongyi Guo, Jianhua Zhu, Hui Shi, Weijuan Huang & Rongmin Yu*. Arca subcrenata polypeptides inhibit human colorectal cancer HT-29 cells growth via suppression of IGF-1R/Akt/mTOR signaling and ATP production. Nut Cancer, 2020, 72(2): 260-272.
[10]Sarwat Fatima#, Xianjing Hu#, Chunhua Huang#, Weixiong Zhang, Jing Cai, Min Huang, Rui-Hong Gong, Minting Chen, Alan H. M. Ho, Tao Su, Hoi Leong Xavier Wong, Zhaoxiang Bian* and Hiu Yee Kwan*. High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner. Cell Death Dis, 2019, 10: 711.
邮箱：huxj2003@163.com
