刘小山导师个人简介 （劳动卫生与环境卫生、卫生毒理学、公共卫生专硕）

刘小山，女，1985年生，博士，环境卫生学教授，研究生导师。2013年于韩国首尔大学公共卫生学院博士毕业后入职广东医科大学公共卫生学院，现为公共卫生学院预防系老师，环境与健康研究所所长，承担预防医学专业《卫生毒理学》、《环境卫生学》等教学工作。广东省“扬帆计划”引进紧缺拔尖人才、东莞市四类特色人才。期间到日本京都大学及美国洛克菲勒大学进行过短期访学。被评为广东医科大学“优秀科技工作者”、高层次人才。学术兼职：广东省毒理学会理事、广东省毒理学会青年常务委员。

主要从事环境有害因素的健康效应、毒作用机制和风险评估研究。研究领域包括：①利用组学、分子生物学等技术手段，结合体外细胞与整体动物，明确环境污染物健康损害的敏感效应生物标志物和毒作用机制。目前聚焦于新型有机磷阻燃剂等持久性有机污染物影响胎盘发育和功能损害妊娠结局和子代发育的作用和机制研究。②建立环境污染物健康损害效应的有害结局路径（AOP），基于AOP开展健康风险评估，为环境污染物的健康风险管理提供理论依据。

近年来主持国家级课题2项，省部级科研课题5项。发表SCI科研论文论文40余篇。其中单篇文章最高引用次数达350次。指导硕士研究生16人，已毕业7人，分别获优秀毕业论文、国家奖学金等。

近5年主持的科研课题

(1) 国家自然科学基金，面上项目，82373614，滋养层细胞PPARγ过度激活抑制胎盘螺旋动脉重塑在孕期磷酸三苯酯暴露诱导子痫前期的作用，2024.1至2017.12，49万，在研，主持

（2）广东省基础与应用基础研究, 面上项目, 2022A1515012195, 阻燃剂磷酸三苯酯干扰胎盘类固醇激素合成诱导不良妊娠结局的作用和机制研究, 2022-01 至2024-12, 10万, 在研, 主持

(3) 广东省基础与应用基础研究, 省市联合, 2021B1515140037, 妊娠期有机磷阻燃剂暴露对子代神经发育的影响与机制研究, 2021-10 至 2024-10, 30万, 在研, 主持

(4) 东莞市社会发展重点项目，20231800935952，新型阻燃剂诱导不良妊娠结局的有害路径和风险评估2023-5 至 2026-4, 8万, 在研, 主持

(5) 广东医科大学高层次人才培养，2020-01至2025-01, 50万, 在研, 主持

近5年发表的一作/通讯文章

(1) Liu, Q.; et al.; Liu, X.* Prenatal triphenyl phosphate exposure and hyperlipidemia in offspring: Role of trophoblast-derived extracellular vesicle PPARγ. Environmental Science & Technology ‌2024‌. DOI: 10.1021/acs.est.4c10800.

(2 ) Lin, J.; et al.; Liu, X*. Exposure to triphenyl phosphate during pregnancy: The role of gut-bile acids-liver axis on lipid metabolism in male offspring. Ecotoxicology and Environmental Safety ‌2024‌, 290, 117554. DOI: 10.1016/j.ecoenv.2024.117554.

(3) Liu, Q.; et al.; Liu, X.* Prenatal triphenyl phosphate exposure impairs placentation and induces preeclampsia-like symptoms in mice. Environmental Research ‌2024‌, 257, 119159. DOI: 10.1016/j.envres.2024.119159.

(4) Chen, Y.; et al.; Liu, X.* Triphenyl phosphate interferes with the synthesis of steroid hormones through the PPAR/CD36 pathway in human trophoblast JEG-3 cells. Environmental Toxicology ‌2024‌, 1-10. DOI: 10.1002/tox.24123.

(5) Lu, X.; et al.; Liu, X.* Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. Science of The Total Environment ‌2023‌, 904, 166688. DOI: 10.1016/j.scitotenv.2023.166688.

(6) Wu, M.; et al.; Liu, X.* Effects of xenobiotic compounds on preeclampsia and underlying mechanism. Toxics ‌2023‌, 11(6), 492. DOI: 10.3390/toxics11060492.

(7) Zhuchen, H.; et al.; Liu, X.*; Shi, Y*. Research progress on neurodevelopmental toxicity in offspring after indirect exposure to PFASs in early life. Toxics ‌2023‌, 11(6), 571. DOI: 10.3390/toxics11060571.

(8) Hong, J.; et al.; Liu, X.* Prenatal exposure to triphenyl phosphate activated PPARγ in placental trophoblasts and impaired pregnancy outcomes. Environmental Pollution ‌2022‌, 301, 119039. DOI: 10.1016/j.envpol.2022.119039.

(9) Hong, J.; et al.; Liu, X.* Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavioral abnormality in male offspring. Ecotoxicology and Environmental Safety ‌2022‌, 243, 113978. DOI: 10.1016/j.ecoenv.2022.113978.

(10) Liu, X.*; et al.; Guo, L. Gestation and lactation triphenyl phosphate exposure disturbs offspring gut microbiota in a sex-dependent pathway. Food and Chemical Toxicology ‌2022‌, 172, 113509. DOI: 10.1016/j.fct.2022.113509.

(11) Liu, X.; et al.; Zhang, J.* Effect of long-term exposure to TDCPP in zebrafish (Danio rerio)-alteration of hormone balance and gene transcriptions along hypothalamus-pituitary axes. Animal Models and Experimental Medicine ‌2022‌, 5(3), 239-247. DOI: 10.1002/ame2.12239.

(12) Wang, Y.; et al.; Tang, H.; Liu, X*. Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells. Chemosphere ‌2021‌, 275, 129978. DOI: 10.1016/j.chemosphere.2021.129978.

(13) Guo, L.; et al.; Liu, X.;* Tang, H*. The mycobiome in murine intestine is more perturbed by food arsenic exposure than in excreted feces. Science of The Total Environment ‌2021‌, 753, 141871. DOI: 10.1016/j.scitotenv.2020.141871.

(14) Liang, H.; et al.; Liu, X.* Removal efficiencies and risk assessment of endocrine disrupting chemicals at two wastewater treatment plants in South China. Ecotoxicology and Environmental Safety ‌2021‌, 225, 112758. DOI: 10.1016/j.ecoenv.2021.112758.

(15) Lin, J.; et al.; Liu, X.* An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues. Steroids ‌2021‌, 166, 108825. DOI: 10.1016/j.steroids.2020.108825.

(16) Liu, X.; et al.; Guo, L.*; Tang, H. Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain. Chemosphere ‌2020‌, 252, 126470. DOI: 10.1016/j.chemosphere.2020.126470.

(17) Liu, X.; et al.; Choi, K.* Effects of tris (1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish. Ecotoxicology and Environmental Safety ‌2019‌, 170, 25-32. DOI: 10.1016/j.ecoenv.2018.11.075.

个人工作和生活照