刘小山导师个人简介 （劳动卫生与环境卫生、卫生毒理学、公共卫生专硕）
刘小山，女，1985年生，博士，副教授，硕士研究生导师。2013年于韩国首尔大学公共卫生学院博士毕业后入职广东医科大学公共卫生学院。期间到日本京都大学及美国洛克菲勒大学进行过短期访学。现为广东医科大学公共卫生学院预防系老师，环境与健康研究所所长。广东省“扬帆计划”引进紧缺拔尖人才、东莞市四类特色人才。被评为广东医科大学“优秀科技工作者”、高层次人才、广东省毒理学会理事、广东省毒理学会青年常务委员。
研究方向为环境毒理学，致力于环境污染物的健康效应与机制研究，利用组学、分子生物学等手段，结合体外细胞与整体动物环境污染物健康损害的有害结局路径和风险评估。目前聚焦于外源化合物经胎盘发育、功能损害影响妊娠结局的研究。同时，与美国洛克菲勒大学Donald Pfaff 院士建立了国际合作，共同致力于环境污染物的代谢干扰效应及机制研究。主持国家级课题1项，省部级5项，校级5项，发表SCI论文30余篇。教学上承担了预防医学专业《卫生毒理学》、《环境卫生学》等教学工作。指导硕士研究生8人，已毕业2人。
近5年主持的科研课题
(1) 广东省基础与应用基础研究, 面上项目, 2022A1515012195, 阻燃剂磷酸三苯酯干扰胎盘类固醇激素合成诱导不良妊娠结局的作用和机制研究, 2022-01 至2024-12, 10万, 在研, 主持
(2) 广东省基础与应用基础研究, 省市联合, 2021B1515140037, 妊娠期有机磷阻燃剂暴露对子代神经发育的影响与机制研究, 2021-10 至 2024-10, 30万, 在研, 主持
(3) 广东医科大学高层次人才培养，2020-01至2025-01, 50万, 在研, 主持
近5年发表的一作/通讯文章
(1) Hong Jiabin, et al., Liu Xiaoshan*. Prenatal exposure to triphenyl phosphate activated PPARγ in placental trophoblasts and impair d pregnancy outcomes. Environmental Pollution, 2022, 301(119039).
(2) Hong Jiabin, et al., Liu Xiaoshan*.Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring. Ecotoxicology and Environmental Safety. 2022, 243,113978.
(3)Liu Xiaoshan*,et al. Guo Lianxian. Gestation and lactation triphenyl phosphate exposure disturbs offspring gut microbiota in a sex-dependent pathway. Food and Chemical Toxicology. 2022, 172, 113509.
(4) Liu Xiaoshan, et al. Choi Kyungho, Zhang Jingjing*. Effect of long-term exposure to TDCPP in zebrafish (danio rerio)-alternation of hormone balance and gene transcriptions along hypothalamus-pituitary axes. Animal Model Experiment Medcine. 2022, doi: 10.1002/ame2.12215.
(5) Wang Yao, et al., Tang Huanwen*, Liu Xiaoshan*. T riphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells. Chemosphere, 2021, 275: 129978.
(6) Guo Lianxian, et al., Liu Xiaoshan*; Tang Huanwen*. The mycobiome in murine intestine is more perturbed by food arsenic exposure than in excreted feces. Science of The Total Environment, 2021, 753: 141871.
(7) Liang Hailong, et al., Liu Xiaoshan*. Removal efficiencies and risk assessment of endocrine disrupting chemicals at two wastewater treatment plants in south China. Ecotoxicology and Environmental Safety, 2021, 225:112758.
(8) Lin Juntong, et al., Liu Xiaoshan*. An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues. Setorids, 2021, 166:108825.
(9) Liu Xiaoshan, et al., Donald Pfaff*. Guo Lianxian*. Tang Huanwen; Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain. Chemosphere, 2020, 252(126470).
(10) Liu Xiaoshan, et al., Choi Kyungho*. Effects of tris (1,3 -dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish. Ecotoxicology and Environmental Safety, 2019, 170: 25-32.
个人工作和生活照
