郭莲仙导师简介

出生年月：1984年5月。学习经历：2001.9-2005.6：华中农业大学，全日制生物工程本科；2005.7-2007.7：中山大学，生物技术，全日制硕士研究生2007.9-2010.7：中山大学，生物技术，全日制博士研究生。工作经历：2010.7至今，就职于广东医科大学公共卫生学院。现任广东医科大学东莞创新研究院副院长、公共卫生学院卫生检验与检疫系主任、国家一流本科专业（广东医科大学-卫生检验与检疫专业）负责人。卫生检验学教授，硕士生导师。

一直从事食品卫生检验领域的研究，涉及到食品有害因素的检测及风险评估、微生物对环境有害因素的响应和代谢机制等方向。尤其关注食物中砷对肠道微生物的影响及微生物与宿主对砷的代谢机制，并取得了突出的成绩。近年来，主持国家自然科学基金2项，广东省自然科学基金4项（含杰出青年基金1项），广东省优秀青年教师培养计划项目1项；以第一作者或通讯作者发表SCI/EI收录论文30余篇，获得授权发明专利2项。

主要科研业绩近3年来以第一作者或通讯作者发表的科研论文（时间倒序排列）：

[1]The gut microbiome promotes arsenic metabolism and alleviates the metabolic disorder for their mammal host under arsenic exposure. Chen L, Li C, Zhong  X, Lai C, Zhang B, Luo Y, Guo H, Liang K, Fang J, Zhu X, Zhang J, Guo L. Environ Int 171 (2023) 107660.

[2]The fecal arsenic excretion, tissue arsenic accumulation, and metabolomics analysis in sub-chronic arsenic-exposed mice after in situ arsenic-induced fecal microbiota transplantation. Luo Y, Wang J, Wang C, Wang D, Li C, Zhang B, Zhong X, Chen L, Li H, Su H, Zheng Q, Zhu D*, Tang H*, Guo L*. Sci Total Environ. 2023; 854:158583.

[3]Polluting characteristics, sources, cancer risk, and cellular toxicity of PAHs bound in atmospheric particulates sampled from an economic transformation demonstration area of Dongguan in the Pearl River Delta, China. Chen Y, Lai B, Wei Y, Ma Q, Liang H, Yang H, Ye R, Zeng M, Wang H, Wu Y, Liu X, Guo L*, Tang H*. Environ Res. 215 (2022) 114383.

[4]In situ analysis of variations of arsenicals, microbiome and transcriptome profiles along murine intestinal tract. Liu X#, Wang J#, Deng H, Zhong X, Li C, Luo Y, Chen L, Zhang B, Wang D, Huang Y, Zhang J*, Guo L*. J Hazard Mater. 2022; 427:127899.

[5] Application of zebrafish in the study of the gut microbiome. Zhong X, Li J, Lu F, Zhang J*, Guo L*. Anim Models Exp Med. 2022;00:1-14.

[6] Microbial diversity analyses of fertilized Thitarodes eggs and soil provide new clues about the occurrence of Chinese cordyceps. Hong Y#, Mai Z#, Li C, Zheng Q, Guo L*. Curr Microbiol. 2022; 79.

[7] Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice. Chen F#, Luo Y#, Li C, Wang J, Chen L, Zhong X, Zhang B, Zhu Q, Zou R, Guo X, Zhou Y*, Guo L*. Ecotoxicol Environ Saf. 2021; 227:112934.

[8] Changes in metabolomics and lipidomics in brain tissue and their correlations with the gut  microbiome after chronic food-derived arsenic exposure in mice. Wang C#, Deng H#, Wang D, Wang J, Huang H, Qiu J, Li Y, Zou T*, Guo L*. Ecotoxicol Environ Saf. 2021; 228:112935.

[9] The mycobiome in murine intestine is more perturbed by food arsenic exposure than in excreted feces. Guo L, Dou X, Zou R, Guo X, Liu X*, Tang H*. Sci Total Environ. 2021; 753:141871.

[10] Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway. Zhang W#, Li L#, Chen H, Zhang Y, Zhang Z, Lin Z, Shi M, Zhang W, Li X, Tang Z, Liu Y, Guo L*, Shi M*. Toxicol lett. 2021; 350:30-39.

[11] Distribution of arsenic species and pathological characteristics of tissues of the mice fed with arsenic-supplemented food simulating rice. Shao J#, Li X#, Luo Y, Fang H, Lin F, Zhang G, Lu F, Guo L*, Sun Y*. J Toxicol Sci. 2021; 46:539-551.

[12] Levels of Pb, Ni, As, and Cd in habitat soils of Chinese Cordyceps in the Shergyla Mountain, Tibet. Liu Y, Xie J, Ma Q, Zhang G, Yu H, Guo L*. Toxicol Environ Chem. 2020; 543-555.

[13] Arsenic concentrations, diversity and co-occurrence patterns of bacterial and fungal communities in the feces of mice under sub-chronic arsenic exposure through food. Wang J, Hu W, Yang H, Chen F, Shu Y, Zhang G, Liu J, Liu Y, Li H*, Guo L*. Environ Int. 2020; 138:105600.

[14] Determination of arsenicals in mouse tissues after simulated exposure to arsenic from rice for sixteen weeks and the effects on histopathological features. Wang J#, Zhang G#, Lin Z, Luo Y, Fang H, Yang L, Xie J, Guo L*. Ecotoxicol Environ Saf. 2020; 200:110742.

[15] Arsenic transfer along the soil-sclerotium-stroma chain in Chinese cordyceps and the related health risk assessment. Liu Y#, Shi M#, Liu X, Xie J, Yang R, Ma Q, Guo L*. PeerJ 2021; 9:e11023.

[16] Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain. Liu X, Zhao X, Wang Y, Hong J, Shi M, Pfaff D, Guo L*, Tang H*. Chemosphere 2020; 252:126470.

[17] Internal and External Microbial Community of the Thitarodes Moth, the Host of Ophiocordyceps sinensis. Liang Y#, Hong Y#, Mai Z#, Zhu Q, Guo L*. Microorganisms 2019; 7:517.

[18] Diversity and Co-Occurrence Patterns of Soil Bacterial and Fungal Communities of Chinese Cordyceps Habitats at Shergyla Mountain, Tibet: Implications for the Occurrence. Shao J#, Lai B#, Jiang W, Wang J, Hong Y, Chen F, Tan S, Guo L*. Microorganisms 2019; 7:284.