主要科研业绩(近5年承担的课题、发表的论文、获奖的成果、授权的专利等)
文章
1、东莞市科技特派员项目(项目号:20221800500172)--《基于社区乳腺癌筛查及“乳消方”对于乳腺良性结节的治疗效果观察》,2022/08-2023/08,10万元,主持(在研)。
2、广东省基础与应用基础研究基金省市联合基金--重点项目(项目号2020B15151 20063),《加味阳和汤联合紫杉醇对阴证乳腺癌脑转移的外泌体miRNA调节机制研究》,2021/01-2024/12,100万,主持(在研)。
3、东莞市社会科技发展基金--重点项目(项目号202050715001207),《围化疗期颊针防治奥沙利铂神经毒性及改善生活质量的临床研究》,2019/01-2022/12,10万,主持(在研)。
4、国家自然科学基金--青年项目(项目号:81803877),《基于PD-L1二聚体形成探索加味阳和汤改善三阴性乳腺癌免疫微环境的机制》, 2018/01-2022/12,21万,主持(在研)。
5、广东省中医药管理局项目(项目号20161260),《探讨补中益气汤通过调控SHP-1基因逆转晚期乳腺癌TAM耐药的机制研究》,2016/04-2018/04,1万,主持(结题)。
6、广东省中医药管理局项目(项目号20131072),《SHP-1在曲妥珠单抗致心脏毒性中的作用及补阳还五汤的调控》,2013/10-2015/10,1万,主持(结题)。
课题
(1) Yifen Wu(第一作者),Rong li,Junyi Zhang,Gang Wang,Bin Liu,Xiaofang Huang,Tao Zhang,Rongcheng Luo. Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2. Onco Target and Therapy.2015:8 2577-2587. (IF=4.147)
(2)Hongyuan Wu, Heling Dong,You Fu,Yu Tang,Meng Dai,Yanya Chen,Gang Wang,Yifen Wu(通讯作者). Expressions of m6A RNA methylation regulators and their clinical predictive value in cervical squamous cell carcinoma and endometrial adenocarcinoma. Clinical and Experimental Pharmacology and Physiology.2021.Feb ;48(2): 270-278(IF=2.557)
(3)Yanting You,Liqian Chen,Yifen Wu(并列第一作者),Ming Wang,Hanqi Lu,Xiaohong Zhou,Huaxi Liu,Zixuan Fu,Qiuxing He,Jingying Qu,Liuqiong Fu,Yanyan Liu,Hiuyee Kwan,Donghui Liang,Xiaoshan Zhao,and Jiaojiao Dai.Silibinin Promotes Cell Proliferation Through Facilitating G1/S Transitions by Activating DrpI-Mediated Mitochondrial Fission in Cell.Cell Transplantetion. 2020,Volumn29: 1-13(IF=4.064)
(4)He-Ling Dong , Hong-Yuan Wu , Zhen-Xiang Tian , Zhi Luo , Yi-Fen Wu(通讯作者),Jun Zhao .Electrical stimulation induces mitochondrial autophagy via activating oxidative stress and Sirt3 signaling pathway .Chinese Medical Journal. 2021;134(5) (IF=2.628)
(5)Yifen Wu(第一作者), Meiling Yang, Rongrong Chen, Sai-Hong Ignatius Ou, Shun Lu.Diverse responses to EGFR-TKIs in patients with concurrent germline and somatic EGFR mutations.Lung Cancer,2021,Dec;162:207-209(IF=5.705)
(6)Yanzhao Ji, Yanting You, Yifen Wu(共同第一), Min Wang , Qiuxing He , Xinghong Zhou , Liqian Chen ,Xiaomin Sun , Yanyan Liu , Xiuqiong Fu , Hiu Yee Kwan , Qiang Zuo , Ren Luo , Xiaoshan Zhao. Overexpression of miR-328-5p influences cell growth and migration to promote NSCLC progression by targeting LOXL4. Annals of Translational Medicine, 2022;10(6):301-318. (IF=3.616)
(7) Xi Zhang, Qing-Hong Chen , Ying Yang , Jing-Xin Lin , Yan-Chun Li , Tian-Yu Zhong , Jie Chen , Si-Qi Wu, Xiao-Hu Chen, Rui-Si Zhou , Jia-Man Lin , Dong-Qing Wang , Qiu-Xing He ,Yanting You , Xinghong Zhou , Qiang Zuo , Yan-Yan Liu 1, Jing-Ru Cheng , Yi-Fen Wu (共同通讯第一), XS Zhao.In Baseline serum uric acid level is associated with progression-free survival, disease control rate, and safety in postoperative patients with colorectal cancer treated by FOLFOX, FOLFIRI or XELOX.Fronties In Oncology, 2022;6(25):1-11. (IF=5.738)